Position Summary 

The internship project will explore de novo molecular design using generative AI models and have a focus on evaluating existing public domain implementations of algorithms for synthetic pathway generation. Collaborating closely with members of the Arvinas CADD team, the intern will configure, run, and deploy generative models. Additionally, the intern will compare the results of the generative methods to evaluate how well they produce synthetically tractable molecules for protein targets of interest. The intern will present results at CADD team meetings and at the conclusion of the internship will summarize their work as a talk or poster at Arvinas. 

This position reports to a Research Investigator, Computational Chemistry and can be located remotely within the U.S.

 Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• Explore generative AI approaches for de novo drug design and synthetic pathway generation.
• Dive deep into molecular datasets, creating statistically rigorous training, validation, and test sets to optimally retrain generative AI models for real-world prediction and generation tasks.
• Run generative methods on protein targets of interests and evaluate the quality of the results with an emphasis on synthetic accessibility of the designed molecules.
• Prepare and present results at an internal Arvinas function at the conclusion of the internship.

Qualifications

• A knowledge of organic chemistry at the undergraduate level or higher is required.
• Proficiency in Python programming required.
• Experience with a cheminformatics toolkit (RDKit, Openeye, Schrodinger, etc.) is required.
• Experience using version control (GitHub, GitLab, Bitbucket, etc.) required.
• Experience working on medicinal chemistry projects is desirable.
• Knowledge of and experience with at least one ML framework (TensorFlow, PyTorch or Keras) is desirable.
• Knowledge of RNNs, LSTMs, Transformers and LLMs is desirable.
• Must be able to work effectively in both independent and team contexts.
• Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without a need for a current or future VISA sponsorship.

 Remote (Home office based):

The duties of this role are generally conducted in a home office environment. Employees must be able, with or without an accommodation to use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving and non-linear thought, analysis, and dialogue; collaborate with others; maintain general availability during standard business hours.

Education

• Computational Chemistry/Biology, Chemistry, Biology, or Computer Science major.
• Completion of classes in Computational Chemistry, Chemistry, and/or Molecular Biology & Biophysics strongly preferred.
• Preference for doctoral graduate students nearing degree completion.

Position Summary

This position will be laboratory-based, working directly with a team of scientists within the Immuno-Oncology Group. The individual will gain first-hand experience in cancer drug discovery by helping to execute and analyze immune cell biology experiments. Within a fast-paced, collaborative environment the individual will be expected to learn quickly and make meaningfully contributions to the progression of potential cancer therapeutics.

This will be a full-time, on-site position located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• Training on various immune-based assays which will then be performed and analyzed with minimal supervision
• Learning methods for assessing protein levels and expression in various bioassays from in vitro cultures including: MSD-based ELISA, qPCR (QuantStudio 6 platform), flow cytometry (BD Fortessa, DIVA, FlowJo), protein quantification via western blot (traditional and higher throughput Jess platform)
• Training and performing immunological cellular functional assays including primary human T cell activation, primary human naïve T cell purification, cytokine production assessment, naïve T cell differentiation/polarization
• Communicating experimental data to team and group members, writing up experimental procedures, and providing thorough documentation using an electronic lab notebook
• Building productive networking relationships
• Demonstrating excellent organizational and prioritization skills

Qualifications

• Prior experience with cell culture is required (preferably immune cells including primary human peripheral blood mononuclear cells, murine splenocytes, naïve human CD4⁺ T cells)
• Prior experience with BD FACs DIVA platform, FlowJo analysis, cytokine ELISA, and qPCR methods is highly desirable
• Proficient understanding of cell and molecular biology and immunology
• Capable of independent work, through record keeping
• Open to constructive feedback, eager to lean, freely ask questions, works well in a collaborative environment
• Proficiency with Microsoft Office Suite
• Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without a need for a current or future VISA sponsorship.
• The duties of this role are generally conducted in a lab environment. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

Education 

• Preference to experienced Masters or Ph.D. level students in immunology, pharmacology, cell biology, or relevant discipline
• Completed advanced coursework in cell biology and/or immunology highly desirable

Position Summary

We are looking for a motivated individual to work as a summer intern (3-4 months) within Neuroscience. This position will be dedicated to conducting experiments and executing assays involving cultured cells, animal tissue, or isolated proteins to develop protein degrader small molecules. This position reports to an Associate Director or another member of the Neuroscience group.

This will be a full-time, on-site position located at our headquarters in New Haven, CT.

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

• >75% lab work: conduct experiments and analytical assays involving cell culture, protein detection, or protein:ligand interactions.
• Execution of assays to query targeted protein degradation: western blots, ELISA, reporter assays, etc.
• Use of lab automation for compound handling.
• Learn protein degrader pharmacology and data analysis.
• Apply excellent organizational skills to maintain lab stocks and lab cleanliness.
• Maintain clear experimental records and communicate well with supervisor and other team members.
• Deliver critical data by following provided protocols and guidance.

Qualifications

• Motivated and productive individual with excellent communication skills who works effectively in a team setting.
• Prior lab experience is required.
  • Experience with antibody-based detection of proteins is strongly preferred.
  • Some experience with 96- or 384-well plate-based assays is preferred (e.g., ELISA, colorometric assays, cell growth assays).
  • Experience with aseptic mammalian cell/tissue culture is required.
• Basic understanding of cell biology, molecular biology, and biochemistry through coursework.
• Organized, goal-oriented, and timeline-conscious.
• Other preferred skills and knowledge.
  • Experimental documentation/lab notebook.
  • Data presentation.
  • Experience with Microsoft Office suite (Word, Excel, PowerPoint).
• A strong work ethic and willingness for continued learning.
• Arvinas will not be providing VISA sponsorship for this position. You must have the ability to work without the need for a current or future VISA sponsorship.  
• The duties of this role are generally conducted in a lab environment. Employees must be able, with or without an accommodation to lift/carry 15/30 pounds unassisted/assisted; work comfortable in a controlled environment with and around biological, infectious and hazardous materials; gown/degown PPE; use a computer; engage in communications via phone, video, and electronic messaging; engage in problem solving, analysis and dialogue; collaborate with others; maintain general availability during standard business hours.

Education

Current 3rd or 4th year undergraduate or a graduate student with a background in the biological sciences and an interest in Neuroscience.